Spirituality of Science: Implications for Meaning, Well-Being, and Learning.

Scientists often refer to spiritual experiences with science. This research addresses this unique component of science attitudes-spirituality of science: feelings of meaning, awe, and connection derived through scientific ideas. Three studies (N = 1,197) examined individual differences in Spirituality of Science (SoS) and its benefits for well-being, meaning, and learning. Spirituality of Science was related to belief in science, but unlike other science attitudes, spirituality of science was also associated with trait awe and general spirituality (Study 1). spirituality of science also predicted meaning in life and emotional well-being in a group of atheists and agnostics, showing that scientific sources of spirituality can provide similar psychological benefits as religious spirituality (Study 2). Finally, Spirituality of Science predicted stronger engagement and recall of scientific information (Study 3). Results provide support for an experience of spirituality related to science, with benefits for meaning, well-being, and learning.

In Doubt and Disbelief: How Mrdjenovich 2018 Misunderstands the (Non)Religion-Health Relationship.

The article, "Religiously/Spiritually Involved, but in Doubt or Disbelief-Why? Healthy?" (Mrdjenovich in J Relig Health. https://doi.org/10.1007/s10943-018-0711-2 , 2018) addressed why subsets of Nones would engage in religious activities. While the subject matter of Mrdjenovich's work is important and understudied, several problematic conclusions about the nonreligion-health field were drawn. We provide constructive criticisms of Mrdjenovich's methodologies, conclusions, and characterizations of the nonreligion-health field, and offer several solutions to the problems identified.

The psychology of nonbelievers.

Contrary to some conceptualizations, nonbelievers are more than simply those scoring low on religiosity scales. They seem to be characterized by analytic, flexible, and open-minded social-cognitive attributes, although this may interact with sociocultural levels of religiosity. This paper demonstrates that nonbelief, at least in the West, tends to coincide with specific worldviews, namely valuing rationality and science, as well as humanistic and liberal values. Furthermore, nonbelievers seem to parallel believers in various indicators of health. Finally, as all ideologists, nonbelievers may hold prejudicial attitudes toward groups perceived as threatening their (secular) worldviews, although this has some limits. Global increases in secularity make the nascent psychological study of nonbelievers and nonreligious worldviews an important research programme.

DMSO-mediated curing of several yeast prion variants involves Hsp104 expression and protein solubilization, and is decreased in several autophagy related gene (atg) mutants.

Chaperones and autophagy are components of the protein quality control system that contribute to the management of proteins that are misfolded and aggregated. Here, we use yeast prions, which are self-perpetuating aggregating proteins, as a means to understand how these protein quality control systems influence aggregate loss. Chaperones, such as Hsp104, fragment prion aggregates to generate more prion seeds for propagation. While much is known about the role of chaperones, little is known about how other quality control systems contribute to prion propagation. We show that the aprotic solvent dimethyl sulfoxide (DMSO) cures a range of [PSI+] prion variants, which are related to several misfolded aggregated conformations of the Sup35 protein. Our studies show that DMSO-mediated curing is quicker and more efficient than guanidine hydrochloride, a prion curing agent that inactivates the Hsp104 chaperone. Instead, DMSO appears to induce Hsp104 expression. Using the yTRAP system, a recently developed transcriptional reporting system for tracking protein solubility, we found that DMSO also rapidly induces the accumulation of soluble Sup35 protein, suggesting a potential link between Hsp104 expression and disassembly of Sup35 from the prion aggregate. However, DMSO-mediated curing appears to also be associated with other quality control systems. While the induction of autophagy alone does not lead to curing, we found that DMSO-mediated curing is dramatically impaired in autophagy related (atg) gene mutants, suggesting that other factors influence this DMSO mechanism of curing. Our data suggest that DMSO-mediated curing is not simply dependent upon Hsp104 overexpression alone, but may further depend upon other aspects of proteostasis.